No, Magento supports only shipping from 1 location by default. However, Magento does offer a multi-source inventory, which is slightly different from multi-origin shipping. Multi-source inventory is a tool that gives you control over your product inventory. It helps retailers to maintain quantities for sales and handle shipments to complete orders better. Furthermore, the feature allows you to track your inventory stock, provide stock amounts to customers, and ship according to recommendations based on distance or priority.
The multi-source inventory feature is meant to be used by retailers who either own a single store or multiple warehouses, drop-off points, or pickup locations. Magento multi-source inventory
helps you grow your business, allowing you to work from a single warehouse or multiple warehouses to benefit from additional settings.
Do not worry though as Calcurates multi-origin shipping is fully compatible with Magento multi-source inventory.